활석을 함유한 지방종: 병리학적 및 물리화학적 연구
Talc Deposition in Lipoma: A Pathologic and Mineralogic Study
대한병리학회지 1999년 33권 11호 p.1024 ~ 1032
김정란, 임현술, 정해관, 김지용, 기요시 사카이, 히사나가 나오미,
소속 상세정보
김정란 ( Kim Jung-Ran )
동국대학교 의과대학 병리학교실
임현술 ( Lim Hyun-Sul )
동국대학교 의과대학 예방의학교실
정해관 ( Cheong Hae-Kwan )
동국대학교 의과대학 예방의학교실
김지용 ( Kim Ji-Yong )
동국대학교 의과대학 예방의학교실
기요시 사카이 ( Kiyoshi Sakai )
일본 나고야시 위생연구소
히사나가 나오미 ( Hisanaga Naomi )
일본 노동성 산업의학총합연구소
KMID : 0357919990330111024
Abstract
Three cases of lipomas associated with heavy talc deposits are reported in local inhabitants near a fiber glass factory. Pathologic and mineralogical analysis by polarizing microscopy, scanning and transmission electron microscopy with energy dispersive X-ray analysis and X-ray diffraction of mass were done. Simultaneously, we performed an epidemiological survey and a mineralogical study of disposed fiber glass from waste site and ground water. All tumors consisted of mature fat tissue containing an abundant birefringent talc fibers and particles under polarized light. The concentrations of the fibers were 494.7, 6.7 and 50.7 million fibers per gram of dry tissue. The fibers were needlelike with rectangular fractured ends, up to 17 μm in length and 0.5 μm in diameter. EDX and X-ray diffraction analysis of the fibers showed that 71 to 100% of the fibers were magnesium silicate, talc. We also identified magnesium silicate fibers in the fiber glass from the waste site and in the ground water which were similar to talc fibers in lipomas,. We concluded that fibrous talc, a component of fiberglass waste, might be associated with the development of lipomas via unknown exposure route.
키워드
Lipoma;Environmental exposure;Talc;Fiber glass;Foreign body
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