위암종에서 Epidermal Growth Factor 관련 펩타이드, EGF-R 및 c-erbB-2의 발현과 예후관련인자와의 관련성
Expression of Epidermal Growth Factor Related Peptides, EGF-R, and c-erbB-2 and Their Relationship with the Prognostic Factors in Gastric Carcinoma
대한병리학회지 1999년 33권 11호 p.1039 ~ 1046
김주헌, 이진욱, 문우성, 강명재, 이동근,
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김주헌 ( Kim Joo-Heon )
전북대학교 의과대학 병리학교실
이진욱 ( Lee Jin-Wook )
전북대학교 의과대학 병리학교실
문우성 ( Moon Woo-Sung )
전북대학교 의과대학 병리학교실 및 의과학연구소
강명재 ( Kang Myoung-Jae )
전북대학교 의과대학 병리학교실 및 의과학연구소
이동근 ( Lee Dong-Geun )
전북대학교 의과대학 병리학교실 및 의과학연구소
KMID : 0357919990330111039
Abstract
Recent investigations have revealed that autocrine growth factors and their receptors are closely related and play an important role in controlling cancer cell growth. We performed an immunohistochemical study on the expression of epidermal growth factor (EGF), transforming growth factor-α (TGF-α), epidermal growth factor receptor (EGF-R), c-erbB-2, and PCNA labelling index in 60 cases of human gastric carcinomas. TGF-α was detected in 38 cases (63.3%), EGF in 26 cases (43.3%), EGF-R in 44 cases (73.3%), and c-erbB-2 in 18 cases (30%). These growth factors, EGF-R and c-erbB-2, were found more often in advanced gastric cancers. The PCNA labeling index was significantly higher in tumors with the expression of EGF-R or c-erbB-2. Tumors with simultaneous expression of EGF, TGF-α, EGF-R and c-erbB-2 was associated with a high PCNA labeling index. A correlation was observed between the synchronous expression of growth factors and its receptors and histological differentiation. The results suggest that the expression of EGF, TGF-α, EGF-R and c-erbB-2 are closely related and plays an important role in the growth and progression of human gastric carcinoma.
키워드
Gastric carcinoma;EGF;TGF-α;EGF-R;c-erbB-2
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