신세포암종의 임상병기와 예후추정인자와의 상관성
Correlation of Clinical Stage and Presumptive Prognostic Factors in Renal Cell Carcinoma
대한병리학회지 1999년 33권 11호 p.1061 ~ 1066
유진예, 조혜제,
소속 상세정보
유진예 ( Yoo Jin-Ye )
인제대학교 의과대학 상계백병원 진단병리과
조혜제 ( Cho Hye-Jae )
인제대학교 의과대학 상계백병원 진단병리과
KMID : 0357919990330111061
Abstract
Renal cell carcinoma is the most common primary cancer of the kidney. The tumor stage is a reliable prognostic marker in renal cell carcinoma which is significantly associated with patient survival. But assessment of other prognostic factors has produced varying and often conflicting results. We reevaluated the significance of varied prognostic parameters in 33 cases of renal cell carcinoma; clinical stage, cell type, histologic pattern, DNA ploidy, Ki-67 labeling index, and bcl-2 oncoprotein expression. We could not statistically prove that DNA ploidy and bcl-2 expression were related to any examined parameters. Cell type was not related to clinical stage nor nuclear grade but there was a significant correlation (p=0.002) between cell type and histologic pattern. Nuclear grade (p=0.007) and Ki-67 labeling index (p=0.036) were significantly related to clinical stage, suggesting their value as complementary prognostic markers for renal cell carcinoma.
키워드
Renal cell carcinoma;Stage;Nuclear grade;Ki-67 labeling index;Bcl-2 expression
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