원발성 피부 림프종 19예의 병리조직학적 소견 및 면역표지자 발현
Histopathologic Features and Immunophenotype of 19 Primary Cutaneous Lymphomas
대한병리학회지 1999년 33권 12호 p.1111 ~ 1119
김희성, 고영혜, 이회정,
소속 상세정보
김희성 ( Kim Hee-Sung )
성균관대학교 의과대학 삼성서울병원 진단병리과
고영혜 ( Ko Young-Hyeh )
성균관대학교 의과대학 삼성서울병원 진단병리과
이회정 ( Ree Howe-J. )
성균관대학교 의과대학 삼성서울병원 진단병리과
KMID : 0357919990330121111
Abstract
The diagnosis of primary cutaneous lymphoma is based on a combination of clinical, histological, immunophenotypic and genetic criteria. Nineteen cases of primary cutaneous lymphomas were studied for clinicopathologic, immunophenotypic, and genetic features. Seventeen (89%) cases were T cell origin and two cases (11%) were B cell origin. CD30-positive cutaneous lymphoproliferative disorder was the most frequent subtype, occupying 42% (8 cases) of the cases. CD8 was positive in 5 cases consisting of 3 cutaneous T cell lymphomas and 2 anaplastic large cell lymphomas. CD4 was positive in 2 cases of mycosis fungoides and 3 cases of lymphomatoid papulosis. Six (67%) of 9 cases of cutaneous T cell lymphoma were positive for TIA-1. Ten (83%) out of 12 cases showed clonal rearrangements of TCR γ genes, however, one T/NK cell lymphoma and one anaplastic large cell lymphoma did not. EBV association was detected only in T/NK cell lymphomas among 10 cases examined. In conclusion, our study showed higher proportion of CD30-positive lymphoproliferative disorders and less frequent mycosis fungoides in Korea compared to the incidences in Western countries. Our immunostaining results suggested that mycosis fungoides and lymphomatoid papulosis are CD4-positive T cell origin, however, the remaining primary cutaneous T cell lymphoma is predominantly CD8-positive cytotoxic T cell origin.
키워드
Primary cutaneous lymphoma;Immunophenotype;Cytotoxic
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