비소세포 폐암종에서 Cyclin D1, p21 및 p53단백의 발현과 예후와의 관계
Relationship among the Expression of Cyclin D1, p21, and p53 Protein, and Prognosis in Non-Small Cell Lung Carcinomas
대한병리학회지 1999년 33권 12호 p.1120 ~ 1130
양석우, 조상호, 양우익, 정우희, 안철민, 이두연,
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양석우 ( Yang Seok-Woo )
연세대학교 원주의과대학 병리학교실
조상호 ( Cho Sang-Ho )
연세대학교 의과대학 병리학교실
양우익 ( Yang Woo-Ick )
연세대학교 의과대학 병리학교실
정우희 ( Jung Woo-Hee )
연세대학교 의과대학 병리학교실
안철민 ( Ahn Chul-Min )
연세대학교 의과대학 내과학교실
이두연 ( Lee Doo-Yun )
연세대학교 의과대학 흉부외과학교실
KMID : 0357919990330121120
Abstract
Recently, cell cycle regulators have been suggested as new prognostic factors of the lung cancer. In this study, we evaluated the expression of cyclin D1, p21, and p53 using the X2-test, with regard to the stage of the patients, histologic type, and histologic differentiation in the 135 cases of non-small cell lung carcinomas (NSCLC). To evaluate the confounding effects among cyclin D1, p21, and p53 on X2-test analysis, we used the Mantel-Haenzel test. The NSCLC in this study included 82 cases of squamous cell carcinoma and 53 cases of adenocarcinoma. Each nuclear staining of cyclin D1, p21, and p53 was observed in 65 cases (48.1%), in 54 cases (40.0%), and in 81 cases (60.0%) of NSCLCs, respectively. Only p53 expression was significantly associated with the stage (stage I, II, IIIa) (p＜0.05) and squamous cell carcinoma (p＜0.05). On the other hand, cyclin D1 expression was significantly associated with the histologic differentiation. The confounding effects among cyclin D1, p21, and p53 revealed that only p21 expression changed the relationship between p53 and stage. In this regard, further study is needed.
키워드
Non-small cell lung carcinoma;Stage;Cyclin D1;p21;p53
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