전립선암종에서 p27kip1 발현과 세포고사 지수
p27kip1 Expression and Apoptotic Index in Prostatic Adenocarcinoma
대한병리학회지 1999년 33권 12호 p.1139 ~ 1145
남은숙, 김덕환, 신형식, 박영의, 양대열,
소속 상세정보
남은숙 ( Nam Eun-Suk )
한림대학교 의과대학 병리학교실
김덕환 ( Kim Duck-Hwan )
한림대학교 의과대학 병리학교실
신형식 ( Shin Hyung-Sik )
한림대학교 의과대학 병리학교실
박영의 ( Park Young-Euy )
한림대학교 의과대학 병리학교실
양대열 ( Yang Dae-Yul )
한림대학교 의과대학 비뇨기과학교실
KMID : 0357919990330121139
Abstract
p27kip1, a cyclin dependent kinase inhibitor, has been recognized as a negative regulator of cell cycle. To investigate the role of p27kip1 on progression of cancer and apoptotic pathway, we analyzed p27kip1 expression using immunohistochemical stain in 40 cases of prostatic adenocarcinoma and apoptotic index by TUNEL method in 30 cases of prostatic adenocarinoma. Both were correlated with Gleason grade and Gleason score. Loss of p27kip1 expression was more frequent in prostatic adenocarcinomas of higher score (Gleason score 7 to 10) (60.7%) than in those of lower score (Gleason score 4 to 6) (33.3%) (p＜0.05). The value of mean apoptotic index of carcinoma was 1.13 0.26, 1.80 0.91, 2.06 0.79, and 2.12 0.82 in grade 2, 3, 4, and 5, respectively, and was positively correlated with grade of carcinoma (p＜0.05). Mean apoptotic index of higher Gleason score (score 7 to 10; 2.05 0.63) was also significantly increased than in lower Gleason score (score 4 to 6; 1.34 0.39) (p＜0.05). Mean apoptotic index in cases with and without p27kip1 expression was 1.92 0.86 and 1.89 0.81, respectively (p＞0.05). These results suggest that loss of p27kip1 expression and increased apoptotic index may be the morphologic markers to predict the behavior of prostatic adenocaricnoma. The role of p27kip1 on apoptotic pathway seems to be meager in this study and needs further study.
키워드
Prostatic adenocaricnoma;Gleason grade;p27kip1;Apoptotic
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