비강과 타액선에서 발생한 Rosai-Dorfman 질환 -1예 보고-
Rosai-Dorfman Disease of the Nose and Salivary Gland -A case report-
대한병리학회지 1999년 33권 12호 p.1203 ~ 1206
노미숙, 정진숙, 홍숙희,
소속 상세정보
노미숙 ( Roh Mee-Sook )
동아대학교 의과대학 병리학교실
정진숙 ( Jeong Jin-Sook )
동아대학교 의과대학 병리학교실
홍숙희 ( Hong Sook-Hee )
동아대학교 의과대학 병리학교실
KMID : 0357919990330121203
Abstract
Rosai-Dorfman disease (RDD) is a rare type of benign histiocytosis characterized histologically by intracellular engulfment of lymphocytes. Extranodal RDD may occur as a part of generalized process involving lymph nodes or may involve extranodal sites independent of the lymph node status. We have experienced a case of extranodal Rosai-Dorfman disease of the nose as an initial lesion prior to nodal involvement. The patient was a 20-year-old woman who complained of nasal obstruction for 4 years, remotely, and left submandibular mass for 3 months, recently. Histologically, the lesion taken from nasal cavity, submandibular gland and left upper jugular lymph node all showed an heavy infiltrate consisted of plasma cells, lymphocytes and sheets of macrophages with abundant pale cytoplasm, which replaced organ architecture. The associated focal fibrosis made it difficult to differentiate from inflammatory pseudotumor. Some macrophages demonstrated phagocytosis of lymphocytes, plasma cells and occasionally neutrophils. The macrophages were strongly positive for S-100 protein.
키워드
Rosai-Dofman disease;Nose;Salivary gland;Inflammatory pseudotumor
원문 및 링크아웃 정보
등재저널 정보