이상 소낭선 병소: 병리조직학적 분류 및 점액분비 양상
Aberrant Crypt Foci: Histopathologic Classification and Profiles of Mucin Secretion
김애리, 최종상, 최원준, 문홍영,
소속 상세정보
김애리 ( Kim Ae-Ree )
고려대학교 의과대학 병리학교실
최종상 ( Choi Jong-Sang )
고려대학교 의과대학 병리학교실
최원준 ( Choi Won-Jun )
건양대학교 의과대학 외과학교실
문홍영 ( Moon Hong-Young )
고려대학교 의과대학 외과학교실
KMID : 0357920000340010050
Abstract
Aberrant crypt foci (ACF) are grossly unidentifiable lesions of the colon and visible only with low-power microscopic examinations after methylene blue stain. To establish the role of ACF in colorectal carcinogenesis, we evaluated the distribution, frequency, histopathological classification, and patterns of mucin secretion of ACF in the colon. A total of 142 aberrant crypt foci were found in 41 colectomy specimen for adenocarcinoma (36 cases) and benign diseases of colon (5 cases). Ten of 142 ACFs were in the ascending and transverse colon, 39 in the descending and sigmoid colon, and 93 in the rectum. The mean number of ACFs in the rectum (0.13 0.11/cm2) was higher than in the ascending and transverse colons (0.019 0.018/ cm2) and descending and sigmoid colon (0.10 0.14/cm2). ACFs were found only in cancer patients. One hundred and twenty ACFs among 142 ACFs identified by topology, were identified on histological examination. We classified ACFs into simple (48.3%), hyperplastic (42.5%), and dysplastic (9.2%) types. All ACFs were infiltrated by the lymphocytes in the stroma and 18 of these accompanied the lymphoid follicles. ACFs have variable histopathologic features and mucin profiles. Some variants of ACFs are at the early stage of the spectrum between benign and malignant.
키워드
Aberrant crypt foci;Colon;Carcinogenesis;Mucin
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