IgA 신병증에서의 Tenascin 발현에 관한 면역조직학적 연구
Immunohistochemical Study on Tenascin Expression in IgA Nephropathy
김호정, 박혜진, 김옥경, 성순희,
소속 상세정보
김호정 ( Kim Ho-Jung )
이화여자대학교 의과대학 병리학교실
박혜진 ( Park Hye-Jin )
이화여자대학교 의과대학 병리학교실
김옥경 ( Kim Ok-Kyung )
이화여자대학교 의과대학 병리학교실
성순희 ( Sung Sun-Hee )
이화여자대학교 의과대학 병리학교실
KMID : 0357920000340010068
Abstract
Glomerulosclerosis is a common outcome in various progressive glomerular diseases, and results from accumulation of extracellular matrices. Depending on the disease progression the extracellular matrices show quantitative and qualitative alterations. Tenascin is a significant extracellular matrix glycoprotein that expresses in normal and pathologic tissue of varying organs including kidney. We performed immunohistochemical staining for tenascin using 30 cases of renal biopsy specimens diagnosed as IgA nephropathy to study the alteration of tenascin expression in IgA nephropathy according to the histologic grading. The results were as follows; 1. The more high histologic grade, the more increase of tenascin was found in the glomerulus. 2. Tenascin was increased in proportion to the mesangial matrix. 3. The staining of tenascin was more intense in glomerular sclerotic area and was increased in proportion to the progression of sclerosis. 4. Cellular crescents showed strong positivity for tenascin. 5. Tenascin was increased in proportion to the degree of interstitial fibrosis in renal cortex. In conclusion, tenascin is an important extracellular matrix component which is significantly increased in both glomerulus and cortical interstitium according to the progress of the disease in IgA nephropathy.
키워드
Kidney;IgA nephropathy;Tenascin;Extracellular matrix
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