진행성 위암종에서 림프절 미소전이의 예후적 유의성
Clinicopathologic Significance of Lymph Node Micrometastasis in Advanced Gastric Carcinoma
권영미, 노재윤, 강경훈,
소속 상세정보
권영미 ( Kwon Young-Mee )
울산대학교 의과대학 서울중앙병원 진단병리학교실
노재윤 ( Ro Jae Y. )
울산대학교 의과대학 서울중앙병원 진단병리학교실
강경훈 ( Kang Gyeong-Hoon )
울산대학교 의과대학 서울중앙병원 진단병리학교실
KMID : 0357920000340020125
Abstract
There have been some controversies on prognostic significance of lymph node (LN) micrometastasis (MM) in advanced gastric carcinomas (AGCs). The present study aimed at 1) determination of prognostic significance of MM, 2) evaluation of the relationship between MM and clinicopathological parameters, and 3) determination of LN group where MMs were frequently found. We studied 70 cases of AGC without LN metastasis on initial examination. The tumors were examined for location, size, depth of invasion, differentiation, histologic type, lymphatic invasion, and c-erbB-2 expression. To evaluate MM, pancytokeratin immunohistochemistry was performed in all LNs from 70 cases of AGCs. Among 2,203 dissected LNs from 70 patients, 37 (1.6%) LNs from 19 (27.1%) patients revealed MM. Micrometastases were seen in only group 1 and 2 LNs: none had group 3 and 4 LN involvement. The gender, age, tumor size, location of tumor, histologic type, differentiation, depth of invasion, lymphatic invasion, and c-erbB-2 expression were not significantly associated with MM status. The survival time of the MM-positive group (mean: 62 months) was significantly shorter than that of the MM-negative group (mean: 72 months) (p=0.046). The findings of this study indicate that the presence of MM in LNs is an important prognostic factor in AGC patients.
키워드
Advanced gastric carcinoma;Cytokeratin;Micrometastasis
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