대장 선암종에서 p27Kip1 단백의 발현
Expression of p27Kip1
이향임, 박혜림, 채승완, 박철재, 김정례, 신형식, 김덕환, 남은숙,
소속 상세정보
이향임 ( Lee Hyang-Im )
한림대학교 의과대학 병리학교실
박혜림 ( Park Hye-Rim )
한림대학교 의과대학 병리학교실
채승완 ( Chae Seoung-Wan )
한림대학교 의과대학 병리학교실
박철재 ( Park Chul-Jae )
한림대학교 의과대학 일반외과학교실
김정례 ( Kim Jeong-Rye )
보훈병원 해부병리과
신형식 ( Shin Hyung-Sik )
한림대학교 의과대학 병리학교실
김덕환 ( Kim Duck-Hwan )
한림대학교 의과대학 병리학교실
남은숙 ( Nam Eun-Suk )
한림대학교 의과대학 병리학교실
KMID : 0357920000340020132
Abstract
p27Kip1 has been recognized as a negative regulator of cell cycle. Reduced level of p27 expression is associated with development and aggressiveness of several human tumors. To investigate the role of p27Kip1 on progression of colorectal adenocarcinoma, we studied 40 cases of human colorectal adenocarcinomas for expression of p27Kip1 protein using an immunohistochemical method, and compared these results with known prognostic parameters of colorectal adenocarcinoma. Among 40 cases of colorectal adenocarcinomas, p27Kip1 expression was detected in the nuclei of tumor cells in 14 cases (35%). The expression rate of p27Kip1 protein was significantly lower in the cases with lymph node metastasis (25.8%) than in those without lymph node metastasis (66.6%) (p＜0.05). But it did not correlate with other parameters such as tumor size, histologic grade, vascular invasion, and Ki-67 labeling index. The results suggest that reduced expression of p27Kip1 protein plays a role in biologically aggressive behavior of colorectal adenocarcinoma.
키워드
Colorectal adenocarcinoma;p27Kip1
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