침윤성 유방암종의 미세혈관밀도 및 Vascular Endothelial Growth Factor 발현
Microvessel Density and Vascular Endothelial Growth Factor Expression in Invasive Breast Carcinomas
전미영, 설미영, 박경선, 윤혜경,
소속 상세정보
전미영 ( Jeon Mi-Yeong )
부산시민병원 해부병리과
설미영 ( Sol Mee-Young )
부산대학교 의과대학 병리학교실
박경선 ( Park Kyung-Sun )
부산백병원 해부병리과
윤혜경 ( Yoon Hye-Kyoung )
부산백병원 해부병리과
KMID : 0357920000340020138
Abstract
Angiogenesis is essential for tumor growth and metastasis, however, the prognostic value of neovascularization is undetermined. The aim of this study is to evaluate the prognostic significance of microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression in breast carcinomas. An immunohistochemical stains for CD 31 (DAKO) to estimate MVD and VEGF (Santa Cruz) were done on 40 cases of invasive breast carcinoma. MVD was calculated as an average count of vessels per 200 power field in the most vascularized areas. VEGF expression was interpreted according to staining intensity and number of positive cells. Mean MVD was 35, and MVD was not correlated with lymph node metastasis or histologic grade, but high MVD (mean MVD＞35) showed an increasing tendency in cases with larger size, negative ER/PR, and positive cathepsin D. All of the cases showed VEGF expression, but VEGF expression was not correlated with tumor size, histologic grade, lymph node metastasis, ER/PR status, and cathepsin D expression. These results suggest that MVD and VEGF expressions are not reliable prognostic factors.
키워드
Microvessel density;VEGF;Breast carcinoma
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