각화극세포종과 고분화 편평세포암종의 조직학적 및 면역조직화학적 특성
Histological and Immunohistochemical Characteristics of Keratoacanthoma and Well Differentiated Squamous Cell Carcinoma
김루시아, 한승경, 이광길,
소속 상세정보
김루시아 ( Kim Lucia )
연세대학교 의과대학 병리학교실
한승경 ( Hann Seung-Kyung )
연세대학교 의과대학 피부과학교실
이광길 ( Lee Kwang-Gil )
연세대학교 원주의과대학 병리학교실
KMID : 0357920000340020145
Abstract
Keratoacanthoma (KA) is a rapidly growing cutaneous tumor and is difficult to distinguish from squamous cell carcinoma (SCC) on histomorphology alone. In the present study, we compared the clinicopathological and immunohistochemical findings using antibodies for p21 (WAF-1/CIP1), p53, laminin, and Ki-67 proteins in 27 cases of KA and 31 cases of well differentiated SCC. KA was characterized by occurrence in sun-exposed skin, shorter duration, and smaller size. Expression of p21 protein was increased according to the maturation and involution of KA, but there was no statistical significance. Expression of Ki-67 was decreased in the involutional stage of KA than in SCC (p＜0.05). But p53 protein and Ki-67 were expressed in the cells at the periphery of both KA and SCC. The immunoexpression pattern of p53 and Ki-67 suggests that proliferative activities of the two lesions are similar. Laminin was present in the infiltrative cell nests of fully developed and involutional stages of KA, and it may be related to the healing process of KA. In conclusion, it is suggested that the degree of proliferative activity in the proliferative and fully developed stages of KA is similar to that of SCC and that p21 gene expression represents the differentiation property of KA and may be associated with its regression.
키워드
Keratoacanthoma;Squamous cell carcinoma;p21 (WAF-1/CIP1);p53;Ki-67;Laminin
원문 및 링크아웃 정보
등재저널 정보