구강 편평세포암종에서 Vascular Endothelial Growth Factor 발현과 미세혈관 밀도
VEGF Exression and Microvessel Density in Oral Squamous Cell Carcinomas
임지준, 홍삼표, 이재일, 홍성두, 임창윤,
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임지준 ( Lim Ji-Jun )
서울대학교 치과대학 구강병리학교실
홍삼표 ( Hong Sam-Pyo )
서울대학교 치과대학 구강병리학교실
이재일 ( Lee Jae-Il )
서울대학교 치과대학 구강병리학교실
홍성두 ( Hong Seong-Doo )
서울대학교 치과대학 구강병리학교실
임창윤 ( Lim Chang-Yun )
서울대학교 치과대학 구강병리학교실
KMID : 0357920000340030190
Abstract
Angiogenesis is an essential process in tumor growth and metastasis. VEGF has been considered a leading candidate inducing tumor angiogenesis. VEGF expression was significantly correlated with clinical stage, lymph node matastasis, and prognosis of cancers of various parts of body. However, little has been known about the correlation between VEGF expression and clinicopathologic parameters in oral squamous cell carcinoma. The aim of this study was to correlate VEGF expression with the clinicopathological parameters and microvessel density. Forty six oral squamous cell carcinomas were analyzed using immunohistochemical method with primary antibodies to VEGF and CD31. VEGF expression was detected in 33 (71.7%) of the 46 cases. The microvessel density was significantly correlated with VEGF expression (P=0.002). There was no correlation between microvessel density and tumour size, clinical stage, and lymph node metastasis, respectively. VEGF expression did not correlate with the histological grade of tumour differentiation, tumour size, and clinical stages. The VEGF-positive rate seemed to be higher in patients with cervical lymph nodal metastasis than in those without it, but it was not statistically significant. In conclusion, the overexpression of VEGF in the oral squamous cell carcinoma seemed to be associated with a more aggressive course of the disease. Further study is necessary to define the role of VEGF in oral squamous cell carcinoma.
키워드
VEGF;Angiogenesis;Oral squamous cell carcinoma;Lymph node metastasis;Microvessel density
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