대장직장암종에서 E-cadherin, α-catenin 및 β-catenin의 발현과 임상병리학적 인자와의 상관관계
Correlation of Expression of E-Cadherin, α-Catenin, β-Catenin, and Clinicopathologic Parameters in Colorectal Adenocarcinomas
김형중, 이태진, 박언섭, 유재형,
소속 상세정보
김형중 ( Kim Hyoung-Joong )
중앙대학교 의과대학 병리학교실
이태진 ( Lee Tae-Jin )
중앙대학교 의과대학 병리학교실
박언섭 ( Park Eon-Sub )
중앙대학교 의과대학 병리학교실
유재형 ( Yoo Jae-Hyung )
중앙대학교 의과대학 병리학교실
KMID : 0357920000340040264
Abstract
The E-cadherin, α-catenin, and β-catenin expressions were immunohistochemically investigated in paraffin-embedded materials of 80 cases of colorectal adenocarcinomas. The staining similar to normal colorectal mucosa with preserved strong membranous staining pattern was considered normal or preserved expression. The χ2 test was used to analyse the statistical correlation of cadherin/catenin expression with clinicopathologic parameters and the Breslow test for the correlation with survival length. Normal colorectal mucosa showed strong membranous expression of cadherin/catenin complex. The reduced E-cadherin, α-catenin, and β-catenin expression were found in 53/80 (66.3%), 46/80 (57.5%), and 44/80 (55.5%) cases of colorectal cancers examined, respectively. There were significant correlations between E- cadherin and α-catenin (p=0.035), and between α-catenin and β-catenin (p=0.013). The reduced E-cadherin expression was associated with histologic dedifferentiation, tumor depth, lymph node metastasis, clinical stage (p＜0.05), poor clinical outcome in stage II (p=0.016) and the reduced α-catenin expression with lymph node metastasis and clinical stage (p＜0.05). Reduced expression of two or more proteins was correlated with lymph node matastasis, histologic dedifferentiation, clinical stage, and survival (p＜0.05). The present study demonstrates a significant down-regulation of E-cadherin and α-catenin expression in colorectal cancer is associated with tumor invasiveness, histologic dedifferentiation, lymph node metastasis, and clinical stage. These results suggest that E-cadherin and α-catenin may be useful markers of invasiveness, lymph node metastatic potential, and clinical stage and of value as prognostic markers in the earlier stage. Further studies are needed to confirm the prognostic value of these cadherin/catenin complex.
키워드
E-cadherin;α-catenin; β-catenin;Colorectal adenocarcinoma;Clinicopathologic parameters
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