갑상선의 유리질 소주형 암종 -2예 보고-
Hyalinizing Trabecular Carcinoma of the Thyroid Gland -A report of two cases-
장규윤, 김주헌, 정명자, 문우성, 강명재,
소속 상세정보
장규윤 ( Jang Kyu-Yun )
전북대학교 의과대학 병리학교실 및 의과학연구소
김주헌 ( Kim Ju-Hun )
을지대학교 의과대학 병리학교실
정명자 ( Chung Myoung-Ja )
전북대학교 의과대학 병리학교실 및 의과학연구소
문우성 ( Moon Woo-Sung )
전북대학교 의과대학 병리학교실 및 의과학연구소
강명재 ( Kang Myoung-Jae )
전북대학교 의과대학 병리학교실 및 의과학연구소
KMID : 0357920000340040318
Abstract
We report two cases of hyalinizing trabecular carcinoma (HTC) of the thyroid gland. These two patients were euthyroid women aged 36 and 65 years of age. The tumors were encapsulated and measured 0.8 and 4.0 cm in diameter, respectively. Histologically, the tumors were composed of a compact proliferation of cells in a lobular and trabecular pattern with an intervening hyalinized, fibrotic vascular stroma. Occasionally the cells were arrayed in microfollicles. Multiple and serial sections showed cords of tumor cells invading into the capsule in both cases and vascular invasion in one case. These findings suggested that HTCs are a malignant counterpart of hyalinizing trabecular adenoma, similar to conventional follicular tumor. Positive immunostaining of tumor cells for thyroglobulin and negative staining for high molecular weight cytokeratin, cytokeratin 19, neuron specific enolase, chromogranin, and synaptophysin allowed distinction from medullary carcinoma. Even though HTCs are an heterogeneous group of tumors, the present two cases are probably variants of follicular carcinoma rather than papillary carcinoma.
키워드
Hyalinizing trabecular carcinoma;Thyroid
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