인체의 다단계 간세포암종 발생과정에서 p21 단백의 발현양상과 세포증식능
p21 Protein Expression and Cell Proliferation Activity in Human Multistep Hepatocarcinogenesis
권계원, 박영년, 박찬일,
소속 상세정보
권계원 ( Kwon Kye-Weon )
포천중문의과대학교 분당차병원 해부병리과
박영년 ( Park Young-Nyun )
연세대학교 의과대학 병리학교실
박찬일 ( Park Chan-Il )
연세대학교 의과대학 병리학교실
KMID : 0357920000340050325
Abstract
p21 is a universal inhibitor of cyclin-dependent kinase (cdk) and of cell-cycle progression. p21 expression is variable according to the type of tissue and the pathologic condition. To study the role of p21 in the multistep hepatocarcinogenesis, the expression of p21, p53 and Ki-67 was investigated in 53 cases of inactive liver cirrhosis, 4 cases of low grade dysplastic nodules, 3 cases of high grade dysplastic nodules, 7 cases of early hepatocellular carcinomas (HCCs), 27 cases of small HCCs (≤3 cm), and 52 cases of advanced HCCs (＞3 cm). p21 expression was not detected in liver cirrhosis, low grade dysplastic nodules, high grade dysplastic nodules and early HCCs which were mitotically inactive. p21 expression was significantly increased in small HCCs and advanced HCCs which were mitotically active. p21 expression was significantly correlated with Ki-67 labelling indices. p53 protein was not expressed in liver cirrhosis, dysplastic nodules, and early HCCs. The expression of p53 protein was, however, significantly increased in small and advanced HCCs. The p21 expression was not correlated with p53 expression. Therefore, p21 is suggested to play a role in the mitotically active small and advanced HCCs, but not in the mitotically inactive lesion of dysplastic nodules and early HCC in multistep hepatocarcinogenesis. These findings suggest that homeostatic mechanism of growth control is not totally destroyed in HCC.
키워드
Hepatocarcinogenesis;Dysplastic nodule;p21;p53;Ki-67
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