유방의 침윤성 관암종에서 MMP-2 및 TIMP-2의 발현과 종양 경계부위의 성장양식, 림프절 전이 및 에스트로겐 수용체 사이의 연관성
Association between the Expresson of MMP-2 and TIMP-2, and Growth Pattern of Tumor Border, Lymph Node Metastasis, and Estrogen Receptor in the Invasive Ductal carcinoma of Breast
민수기, 염범우, 김준미, 주영채, 조영업,
소속 상세정보
민수기 ( Min Soo-Kee )
인하대학교병원 해부병리학교실
염범우 ( Yeom Bom-Woo )
고려대학교 의과대학 병리학교실
김준미 ( Kim Joon-Mee )
인하대학교병원 해부병리학교실
주영채 ( Chu Young-Chae )
인하대학교병원 해부병리학교실
조영업 ( Cho Young-Up )
인하대학교병원 일반외과
KMID : 0357920000340050366
Abstract
The most important prognostic factor of breast cancer is the status of lymph node or distant metastasis, which is resisted by basement membrane and stromal matrix. MMP (matrix metalloproteinase)-2 is a 72-kilodalton type IV collagenase/ gelatinase and degrades the type IV collagen which is a main component of the basement membrane. Therefore, MMP-2 is believed to be one of the key molecule for cancer invasion and metastasis. Enzymatic activity of MMP is inhibited by TIMPs (tissue inhibitors of metalloproteinase). TIMP-2 forms a complex with latent pro-MMP-2 and inhibits the active forms of MMP-2. The balance of MMPs and TIMPs is suspected as the important factor of invasion and metastasis of the tumor cells. We studied the association between the expression of MMP-2/TIMP-2 and growth pattern of tumor border, lymph node metastasis, and estrogen receptor expression in the 57 cases of invasive ductal carcinoma of the breast using immunohistochemical staining methods. The results revealed increased expression of MMP-2 in the infiltrating tumor border and tumors with positive lymph node metastasis and negative estrogen receptor with no statistical significance (p＞0.05). But the expression of TIMP-2 was increased in expanding tumor border and tumors with positive lymph node metastasis and negative estrogen receptor without statistical significance (p＞0.05).
키워드
MMP 2;TIMP 2;Growth pattern Metastasis;Invasive ductal carcinoma
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