방사선치료 후 발생한 간소정맥 폐쇄질환 -3예 보고-
Hepatic Veno-occlusive Disease Developed after Irradiation -A report of three cases-
하경수, 김세훈, 박영년, 박찬일,
소속 상세정보
하경수 ( Har Kyoung-Soo )
연세대학교 의과대학 병리학교실
김세훈 ( Kim Se-Hoon )
연세대학교 의과대학 병리학교실
박영년 ( Park Young-Nyun )
연세대학교 의과대학 병리학교실
박찬일 ( Park Chan-Il )
연세대학교 의과대학 병리학교실
KMID : 0357920000340050381
Abstract
Hepatic veno-occlusive disease (VOD) is a rare disease due to occlusion of the terminal hepatic venules and/or sublobular veins, which is a result of endothelial damage from pyrrolizidine alkaloids in herbal teas, irradiation of the liver, or chemotherapy particularly in association with bone marrow transplantation. We recently experienced three cases of VOD developed after radiation therapy. Two cases occurred in hepatocellular carcinoma patients of a 37-year-old man with B viral chronic hepatitis and a 22-year-old man with B viral cirrhosis and the other in a 64-year-old patient with esophageal squamous cell carcinoma. For the treatment of hepatocellular carcinoma, chemoembolization with lipiodol and adriamycin, and external irradiation on the liver mass were done. The total radiation dose was 5400 cGy and 3000 cGy in each case. Five months and 3 months after irradiation, respectively, the resected liver masses showed extensive necrosis due to pre-operative treatment. To treat esophageal carcinoma, pre-operative concurrent chemotherapy of 5-FU and radiation of 4500 cGY were done. One month after irradiation, the radical esophgectomy and wedge biopsy of the liver were done. The liver of all 3 cases showed a dark red appearance with severe congestion in contrast to the pale brown normal liver, which was not included in the radiation field. On micoscopic examination, the terminal hepatic venules and sublobular veins showed subintimal edema, fibrin deposition, and partial or total luminal occlusion by loose fibrous tissue. The centrizonal sinusoids were markedly dilatated and congested with atrophy of hepatocytes.
키워드
Venoocclusive disease;Irradiation;Liver
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