특발성 골수섬유증에서 발생한 비간경변성 문맥고혈압 -1예 보고-
Non-cirrhotic Portal Hypertension in Idiopathic Myelofibrosis -A case report-
김성은, 박영년, 양우익, 최진섭, 박찬일,
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김성은 ( Kim Sung-Eun )
연세대학교 의과대학 병리학교실
박영년 ( Park Young-Nyun )
연세대학교 의과대학 병리학교실
양우익 ( Yang Woo-Ick )
연세대학교 의과대학 병리학교실
최진섭 ( Choi Jin-Sub )
연세대학교 의과대학 외과학교실
박찬일 ( Park Chan-Il )
연세대학교 의과대학 병리학교실
KMID : 0357920000340050386
Abstract
We report a case of non-cirrhotic portal hypertension in a 73 year-old woman, who had 19-year history of idiopathic myelofibrosis. There were esophageal varix, splenomegaly, and ascites. The biopsied liver showed irregular sinusoidal/ perisinusoidal fibrosis and occasional central-to-central fibrous connection. In areas with extensive fibrosis, coarse collagen fibers filled the sinusoidal spaces and compressed hepatocytes. However, nodular regeneration was absent. Double immunohistochemical stain for smooth muscle actin and proliferation cell nuclear antigen (PCNA) revealed diffusely activated stellate cells, some of which showed nuclear PCNA staining. There was also extramedullary hematopoiesis with bizarre megakaryocytes. The portal vein and its branches were patent. Idiopathic myelofibrosis is a rare cause of non-cirrhotic portal hypertension: the portal hypertension was considered to be the result of sinusoidal/perisinusoidal fibrosis in this case.
키워드
Myelofibrosis;Liver;Fibrosis;Non-cirrhotic portal hypertension
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