5-Fluorouracil 투여에 의한 백서 흉선의 Apoptosis
Apoptosis in Rat Thymus after Bolus Intramuscular Injection of 5-Fluorouracil
김경희, 설혜정, 강대영,
소속 상세정보
김경희 ( Kim Kyung-Hee )
충남대학교 의과대학 병리학교실
설혜정 ( Sul Hae-Joung )
충남대학교 의과대학 병리학교실
강대영 ( Kang Dae-Young )
충남대학교 의과대학 병리학교실
KMID : 0357920000340060413
Abstract
We induced apoptosis in normal rats by intramuscular injection of 5-fluorouracil (5-FU) and immunohistochemically evaluated the thymus for the TdT-mediated dUTP biotin nick end labelling on the 1st, 3rd, 6th, 9th, 15th and 21st days following the bolus intramuscular injection. The injections of 5-FU induced a greater extent of apoptosis in the thymus. In the thymus, a mild increase in apoptosis was observed 24 hours after injection. The greatest number of apoptotic cells were seen at 72 hours. The size of the thymus decreased and the cortex thinned with hypocellularity. The injection of 5-FU caused massive cell loss in the thymus. Most apoptotic cells were scattered in the cortex and lower levels of apoptosis were also observed in the medulla. After 72 hours, the level of apoptosis returned to the control level. Considering the above results, we think that 5-FU induced toxicity may be related to 5-FU induced apoptosis in normal tissue, especially the thymus.
키워드
Apoptosis;5-fluorouracil
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