DNA 복제이상을 보이는 한국인 위선암종의 임상병리학적 특징
Clinicopathologic Characteristics of Replication Error-Positive Gastric Adenocarcinoma in Korean
이제혁, 김미화, 이완식, 김영진, 지미선, 이광민, 정상우, 최찬,
소속 상세정보
이제혁 ( Lee Jae-Hyuk )
전남대학교 의과대학 병리학교실
김미화 ( Kim Mi-Hwa )
전남대학교 의과대학 병리학교실
이완식 ( Lee Wan-Sik )
전남대학교 의과대학 내과학교실
김영진 ( Kim Young-Jin )
전남대학교 의과대학 외과학교실
지미선 ( Jee Mi-Sun )
동아병원 내과
이광민 ( Lee Kwang-Min )
예수병원 해부병리과
정상우 ( Juhng Sang-Woo )
전남대학교 의과대학 병리학교실
최찬 ( Choi Chan )
전남대학교 의과대학 병리학교실
KMID : 0357920000340070488
Abstract
The purpose of this study is to obtain the clinicopathological characteristics of replication error-positive (RER+) gastric adenocarcinoma in Korean, and to identify the significance of RER+ in adenoma stage of gastric carcinogenesis. Microsatellite instability was examined at D2S71, D2S119, D3S1067, D6S87, D11S905, DM, AR, VWF, HPRT, and BAT-26 loci. Frameshift mutation of BAX gene was analyzed in RER+ tumors. Normal and tumor DNA of 76 cases of gastric carcinoma and 25 cases of adenoma were examined. RER+ was found in 8 of 76 cases (10.5%), and it was more frequently found in adenocarcinoma of female (17.7%) than those of male (4.8%). The frequency of RER+ was not different between the histologic types, age of the patient, anatomical location of the carcinoma, and the stage. The RER+ found in adenoma suggests that RER+ contributes to the malignant transformation early in the adenoma stage of the gastric carcinogenesis. None of the RER+ tumors revealed frameshift mutation of the BAX gene.
키워드
Gastric adenocarcinoma;Microsatellite instability;Replication error phenotype;BAX;Clinicopathologic characteristics
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