결직장 선암종에서 p53 및 Matrix Metalloproteinase-2 단백의 발현
Expression of p53 and Matrix Metalloproteinase-2 Proteins in Colorectal Adenocarcinoma
조성진, 오화은, 채양석,
소속 상세정보
조성진 ( Cho Seong-Jin )
고려대학교 의과대학 병리학교실
오화은 ( Oh Hwa-Eun )
관동대학교 의과대학 명지병원 해부병리과
채양석 ( Chae Yang-Seok )
고려대학교 의과대학 병리학교실
KMID : 0357920000340070494
Abstract
The p53 gene is believed to play an important role through the mutation and overexpression in the progression of various human malignant tumors. The type IV collagenase (matrix metalloproteinase: MMP-2) initiates the degradation of the extracellular matrix, and consequently may play a role in the tumor invasion and metastasis. To investigate the correlation between clinicopathologic features of the colorectal adenocarcinomas and benign tumors and expression of p53 and MMP-2 proteins, we performed an immunohistochemical study on 40 colorectal adenocarcinomas, 20 adenomas and 20 hyperplastic polyps by using the antibodies to p53 and MMP-2 proteins. The positive expression rate of the p53 protein in adenocarcinomas was 62.5% and significantly higher than in benign tumors. The positive expression rate of the MMP-2 protein was 47.5% in adenocarcinomas, but there was no expression of MMP-2 protein in benign tumors. The difference in p53 and MMP-2 expression rates between malignant and non-malignant tumors was statistically significant. The positive expression rate of p53 protein in the non-metastatic and metastatic adenocarcinomas was 59.1 and 66.7%, respectively. The positive expression rate of MMP-2 protein in the non-metastatic and metastatic adencarcinomas was 45.5 and 50.0%, respectively. The correlation between several clinicopathologic features and expression of p53 and MMP-2 protein was not statistically significant, but the rate of positive MMP-2 immunoreactivity showed a statistically significant difference between Astler-Coller stage B1+C1 group and B2+C2 group of adenocarcinoma (p=0.0431). We concluded that the expression of p53 and MMP-2 protein contributes to the cancer development and MMP-2 may play a certain role in the invasiveness of the colorectal tumor. p53 and MMP-2 protein expression is not correlated with lymph node metastasis.
키워드
Colorectal adenocarcinoma;P53;MMP-2;Tumor invasion;Metastasis
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