결직장암에서 Met 단백의 발현
Expression of Met Protein in Colorectal Carcinoma
최경운, 이진숙, 이창훈, 설미영, 서강석,
소속 상세정보
최경운 ( Choi Kyung-Un )
부산대학교 의과대학 병리학교실
이진숙 ( Lee Jin-Sook )
부산대학교 의과대학 병리학교실
이창훈 ( Lee Chang-Hun )
부산대학교 의과대학 병리학교실
설미영 ( Sol Mi-Young )
부산대학교 의과대학 병리학교실
서강석 ( Suh Kang-Suk )
부산대학교 의과대학 병리학교실
KMID : 0357920000340070501
Abstract
Met protein is a transmembrane 190 kD heterodimer with tyrosine kinase activity, encoded by c-Met oncogene. It serves as a high affinity receptor for hepatocyte growth factor (HGF)/scatter factor (SF), a cytokine which stimulates cell proliferation, motility, and invasion. In this study, we immunohistochemically evaluated the expression of Met/hepatocyte growth factor receptor in colorectal cancers. Met protein was expressed in 31 of 72 patients (43.1%). The staining pattern was cytoplasmic in nature, present throughout the tumor, and showed variable intensity from case to case. The relationship between the expression rate and intensity, and age and sex of patients, tumor size (p=0.645), tumor site (p=0.902) and tumor differentiation (p=0.844) was not statistically significant. The expression rate and intensity were significantly correlated with lymphovascular invasion (p=0.001), lymph node metastasis (p=0.010), depth of invasion (0.019), and stage (p=0.023). Cytoplasmic accumulation of Met protein was not associated with enhanced PCNA index of tumor cells (p=0.052). These results suggest that Met protein may play an important role in the invasion and metastasis of colorectal cancer cells.
키워드
Colorectal;Carcinoma;Met protein;Hepatocyte growth factor;PCNA
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