색소성 종격동 부신경절종 -1예 보고-
Pigmented Mediastinal Paraganglioma -A case report-
김성호, 진윤희, 홍은경, 박문향,
소속 상세정보
김성호 ( Kim Seong-Ho )
한양대학교 의과대학 병리학교실
진윤희 ( Jin Yoon-Hee )
한양대학교 의과대학 병리학교실
홍은경 ( Hong Eun-Kyung )
한양대학교 의과대학 병리학교실
박문향 ( Park Moon-Hyang )
한양대학교 의과대학 병리학교실
KMID : 0357920000340080597
Abstract
Pigmented extraadrenal paraganglioma is an unusual neoplasm that has rarely been reported in the literature. Based on histochemical staining or electron microscopy, pigment has been classified as lipofuscin, neuromelanin or true melanin. We report a case of pigmented extraadrenal paraganglioma in the posterior mediastinum of a 70-year-old woman. Histologically, the tumor had a characteristic organoid architecture of "zellballen" pattern with rich delicate microvasculature. Tumor cells contained numerous coarse brown-black pigment granules. Ultrastructurally, the tumor showed abundant large electron-dense pigment granules that vary in size and shape and smaller membrane-bound neurosecretory granules. The larger granules were consistent with neuromelanin or lipofuscin. Histochemically, the pigment is most likely neuromelanin, which is a waste product of catecholamine metabolism.
키워드
Paraganglioma;Mediastinum;Neuromelanin;Melanin
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