경부 림프절의 전이성 암종과 원발성 암종에서 p53, E-cadherin 및 nm23 단백의 발현
Immunohistochemical Expression of p53, E-cadherin, and nm23 Proteins in Metastatic Carcinoma of Neck Lymph Node and Corresponding Primary Carcinoma
김종국, 권오준, 김병헌,
소속 상세정보
김종국 ( Kim Jong-Kook )
성균관대학교 의과대학 마산삼성병원 해부병리과
권오준 ( Kwon O-Jun )
성균관대학교 의과대학 마산삼성병원 해부병리과
김병헌 ( Kim Byung-Heon )
성균관대학교 의과대학 마산삼성병원 해부병리과
KMID : 0357920000340090615
Abstract
This study was carried out to evaluate the immunohistochemical expressions of p53, E-cadherin, and nm23 proteins in 114 cases of metastatic carcinoma of the neck lymph node (MTLNCA) and corresponding primary carcinoma (PRCA). The positive expressions of p53, E-cadherin, and nm23 proteins were 62.3%, 58.8% and 64.0%, respectively in PRCA, and 40.4%, 38.6%, and 43.9%, respectively in MTLNCA with significant down-regulation from PRCA to MTLNCA (p＜0.05). The down-regulation was correlated with female gender, moderate and poor differentiation, and adenocarcinoma in p53 protein, female gender, respiratory and gastrointestinal carcinoma in E-cadherin protein, and female gender, respiratory carcinoma, moderate differentiation, and squamous cell carcinoma in nm23 protein (p＜0.05). There was no significant relationship among expressions of p53, E-cadherin, and nm23 proteins (p＞0.05). In conclusion, these results suggest that the expressions of p53, E-cadherin, and nm23 proteins seem to be down-regulated from PRCA to MTLNCA and this down-regulation may play a role in invasion and metastasis.
키워드
Metastatic carcinoma;Neck lymph node;p53;E-cadherin;nm23
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