태아를 동반한 완전 포상기태 -1예 보고-
Complete Hydatidiform Mole with a Coexisting Fetus -A case report-
전이경, 김혜선, 김의정, 김희숙, 최수경, 박소연, 홍성란,
소속 상세정보
전이경 ( Chun Yi-Kyeong )
성균관대학교 의과대학 삼성제일병원 병리과
김혜선 ( Kim Hye-Sun )
성균관대학교 의과대학 삼성제일병원 병리과
김의정 ( Kim Yee-Jeong )
성균관대학교 의과대학 삼성제일병원 병리과
김희숙 ( Kim Hy-Sook )
성균관대학교 의과대학 삼성제일병원 병리과
최수경 ( Choi Soo-Kyung )
성균관대학교 의과대학 삼성제일병원 유전학 연구실
박소연 ( Park So-Yeon )
성균관대학교 의과대학 삼성제일병원 유전학 연구실
홍성란 ( Hong Sung-Ran )
성균관대학교 의과대학 삼성제일병원 병리과
KMID : 0357920000340090673
Abstract
Twin conceptus of a complete hydatidiform mole (CHM) and a normal fetus are rare but are important because of diagnostic difficulty, problems related to twin pregnancy, and high risk of persistent gestational trophoblastic tumor. Recently, we experienced one case of twin pregnancy consisting of a CHM and a normal fetus. A 26-year-old woman complained of vaginal bleeding. She had evidences of pregnancy-induced hypertension. A male fetus was delivered at 20 gestational weeks. The placenta demonstrated vesicles of molar change separated from normal placenta. Microscopically, the molar villi disclosed diffuse hydropic swelling with circumferential trophoblastic proliferation. DNA flow cytometric analysis showed diploid patterns in both molar and normal placental tissues. Fluorescent in situ hybridization in paraffin-embedded tissue presented that normal placental villi hybridized with X- and Y-chromosome probes (46, XY), while molar villi hybridized with X-chromosome only (46, XX). Thus, dizygotic twinning was confirmed because sex differences were shown between molar villi and normal placental villi. Follow up β-hCG was within normal range after delivery.
키워드
Complete hydatidiform mole;Twin;Fluorescent in situ hybridization
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