자궁경부 편평상피종양에서 bvl-2 및 Caspase-3 발현과 종양증식능의 연관성
Correlation between bcl-2 and Caspase-3 Expression and Proliferating Activity in Squamous Neoplasia of the Uterine Cervix
박경선, 강미선, 윤혜경,
소속 상세정보
박경선 ( Park Kyung-Sun )
인제대학교 의과대학 부산백병원 해부병리학교실
강미선 ( Kang Mi-Seon )
인제대학교 의과대학 부산백병원 해부병리학교실
윤혜경 ( Yoon Hye-Kyoung )
인제대학교 의과대학 부산백병원 해부병리학교실
KMID : 0357920000340110919
Abstract
Detailed mechanism of uterine cervical cancer progression still remains unclear. Altered programmed cell death (apoptosis) and cellular proliferation are associated with the development of neoplasia. The authors investigated the expressions of bcl-2, which inhibit apoptosis, and caspase-3, which is involved in the induction of apoptosis and has been considered to be correlated with apoptosis, and proliferating activity according to the degree of malignancy in the squamous neoplasia of the uterine cervix. Correlation between bcl-2 and caspase-3 expression and proliferating activity was done. The materials were low grade squamous intraepithelial lesions (LSIL, n=15), high-grade squamous intraepithelial lesions (HSIL, n=15), microinvasive squamous cell carcinoma (n=15), and squamous cell carcinoma (n=15). Immunohistochemical stainings for bcl-2, caspase-3, and MIB-1 were done. bcl-2 and MIB-1 expressions were progressively increased in accordance with the increasing degree of malignancy, but caspase-3 immunoreactivity was higher in LSIL than invasive cancers. There was an inverse relationship between bcl-2 and caspase-3 expression, but the difference did not reach statistical significance. No significant correlation between MIB-1, bcl-2, and caspase-3 expressions was observed. These results suggest that an inhibition of apoptosis and the augmentation of proliferating activity of tumor cells might be separately involved in the development of the cervical squamous neoplasia.
키워드
bcl-2;Caspase-3;MIB-1;Uterine cervix
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