폐의 편평세포암종과 선암종에서 E-Cadherin, Matrix Metalloproteinase;Vascular Endothelial Growth Factor의 발현
Expression of E-cadherin, Matrix Metalloproteinase, and Vascular Endothelial Growth Factor in Squamous Cell Carcinoma and Adenocarcinoma of the Lung
송지선, 조미연, 박광하, 정순희, 이광길,
소속 상세정보
송지선 ( Song Ji-Sun )
연세대학교 원주의과대학 병리학교실
조미연 ( Cho Mee-Yon )
연세대학교 원주의과대학 병리학교실
박광하 ( Park Kwang-Hwa )
연세대학교 원주의과대학 병리학교실
정순희 ( Jung Soon-Hee )
연세대학교 원주의과대학 병리학교실
이광길 ( Lee Kwang-Gil )
연세대학교 원주의과대학 병리학교실
KMID : 0357920000340120972
Abstract
E-cadherin is a calcium-dependent epithelial adhesion molecule which plays a role in the initial step of invasion of cancer cells. The step that follows the migration of separated tumor cells is a proteolytic lysis of basement membrane and extracellular matrix by protease of epithelial and endothelial cells such as matrix metalloproteinase (MMP). Vascular endothelial growth factor (VEGF) is known to be an endothelial cell-specific powerful mitogen as well as a vascular permeability factor. This study is aimed to evaluate the correlation between expression of these factors and pathologic or clinical variables and the roles and prognostic significance of those factors in squmous cell carcinoma and adenocarcinoma of the lung. Immunohistochemical stains were performed for E-cadherin, MMP-2, and VEGF in surgically resected specimens from 90 patients with squmous cell carcinoma and adenocarcinoma of the lung. Mean age of the patients was 59.7 years. Histologic type was categorized into 56 cases of squamous cell carcinoma and 34 cases of adenocarcinoma. Mean survival period of the 35 patients was 54 months. The immunohistochemical stains for E-cadherin, MMP-2, and VEGF revealed positive reaction in 67 cases (74.4%), 43 cases (47.8%), and 34 cases (37.8%), respectively. The expression of E-cadherin was higher in adenocarcinoma (82.4%) than in squamous cell carcinoma (69.6%). MMP-2 was expressed in the tumor cells, especially those invading into the surrounding stroma. The expression of MMP-2 was significantly correlated with the survival rate (p＜0.05). The expression of VEGF in the tumor cells was significantly higher in cases with lymph node metastasis (p＜0.05). In conclusion, these findings suggest that the expression of MMP-2 and VEGF predict poor prognosis of patients with squmous cell carcinoma and adenocarcinoma of the lung and that VEGF may play a role in tumor metastasis.
키워드
Non-small cell lung carcinoma;E-cadherin;Matrix metalloproteinase;Vascular endothelial growth factor;Prognostic factor
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