갑상선 여포선종과 여포암종에서 SPARC의 발현
SPARC Expression in Thyroid Follicular Adenomas and Carcinomas
대한병리학회지 2000년 34권 12호 p.1016 ~ 1021
김정열, 조성진, 김민경, 채양석,
소속 상세정보
김정열 ( Kim Chung-Yeul )
고려대학교 의과대학 병리학교실
조성진 ( Cho Seong-Jin )
고려대학교 의과대학 병리학교실
김민경 ( Kim Min-Kyung )
고려대학교 의과대학 병리학교실
채양석 ( Chae Yang-Seok )
고려대학교 의과대학 병리학교실
KMID : 0357920000340121016
Abstract
SPARC, secreted protein acidic and rich in cysteine, is a extracellular matrix-associated protein implicated in the modulation of cell adhesion, migration, cell cycle regulation, and angiogenesis. SPARC is expressed in fibrocytes and endothelial cells involved in tissue repair and invasive malignant tumors in the gastrointestinal tract, breast, lung, kidney, adrenal cortex, ovary, and brain. This study was aimed to characterize the different expression of SPARC in the thyroid follicular adenomas and follicular carcinomas. Immunohistochemical staining was performed in paraffin-embedded tissues of 25 follicular adenomas and 15 follicular carcinomas of the thyroid gland. Immunohistochemically, SPARC was not expressed in the 19 follicular adenoma and 2 follicular carcinoma but highly expressed in the 6 follicular adenoma and 13 follicular carcinoma. These findings suggest that SPARC is a potential diagnostic marker of follicular carcinoma and is helpful to distinguish follicular carcinoma from follicular adenoma without vascular or capsular invasion.
키워드
SPARC;Thyroid;Follicular carcinoma;Follicular adenoma
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