한국인 전립선 선암종의 병리학적 특성: 60예에 대한 지도화 분석
Pathologic Characteristics of Korean Prostatic Adenocarcinoma: A Mapping Analysis of 60 Cases
최윤라, 김성림, 송상용, 최한용,
소속 상세정보
최윤라 ( Choi Yoon-La )
성균관대학교 의과대학 삼성서울병원 진단병리과
김성림 ( Kim Sung-Rim )
성균관대학교 의과대학 삼성서울병원 진단병리과
송상용 ( Song Sang-Yong )
성균관대학교 의과대학 삼성서울병원 진단병리과
최한용 ( Choi Han-Yong )
성균관대학교 의과대학 삼성서울병원 비뇨기과학교실
KMID : 0357920010350010035
Abstract
Background: Pathologic characteristics of the prostatic adenocarcinoma in Korean patients are not clear. We studied 60 cases of radical prostatectomy specimens using mapping analysis in an effort to discover the pathologic characteristics of the Korean prostatic adenocarcinoma.
Methods: A resected prostate was sectioned serially and embedded near-totally. Gleason score, tumor volume or size, capsular extension, involvement of lateral margin, seminal vesicle, vas, apex and base, presence of lymphatic and neural invasion, and presence of high grade prostatic intraepithelial neoplasm (HGPIN) were examined. DNA ploidy and proliferative index were evaluated.
Results: Mean values were as follows: age, 63.6 years; serum prostate specific antigen level (sPSA), 24.0 ng/ml; tumor amount (volume, 29.1%; size, 2.4 cm); Gleason score, 7.3; aneuploidy, 23.3%; proliferative index, 14.2%. Involvement rates of apex, base, seminal vesicle, resection margin, nerve and lymphatics were 5.2%, 39.0%, 23.7%, 31.7%, 56.7% and 16.7%, respectively. Rates of multifocal tumors and HGPIN were 43.3% and 63.3%, respectively. The Gleason score was correlated with tumor amount (volume%, p<0.001; size, p<0.01) and tumor extent (T) (p<0.005). Tumor amount was correlated with sPSA (p<0.05) and T (p<0.005). T was correlated with sPSA (p<0.05).
Conclusion: Korean prostatic adenocarcinomas showed higher Gleason scores, lower HGPIN rates and multifocalities in comparison to western prostatic adenocarcinomas, suggestive of the Korean prostatic adenocarcinomas’ late detection.
키워드
Prostate;Neoplasm;Pathology;Korean
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