자궁경부 선상피 질환에서 MIB-1, p53, CEA의 발현
Expressions of MIB-1, p53 and CEA in Endocervical Glandular Lesions
김미진, 이영기, 김동석,
소속 상세정보
김미진 ( Kim Mi-Jin )
영남대학교 의과대학 병리학교실
이영기 ( Lee Young-Gi )
영남대학교 의과대학 산부인과학교실
김동석 ( Kim Dong-Sug )
영남대학교 의과대학 병리학교실
KMID : 0357920010350010041
Abstract
Background: Endocervical glandular lesions include glandular atypia (GA), endocervical glandular dysplasia (EGD), adenocarcinoma in situ (AIS), and invasive adenocarcinoma (IA). The diagnosis of malignant glandular lesions is occasionally difficult to distinguish from benign mimickers, and the morphologic features of EGD remain unsettled.
Methods: Immunohistochemical stains for MIB-1, p53 and CEA were performed on 81 cases of paraffin- embedded endocervical glandular lesions including 22 IA, 15 AIS, 15 EGD, 13 GA, 8 microglandular hyperplasia (MGH) and 8 tubal metaplasia (TM).
Results: The MIB-1 labelling index of IA was 59.68%, 69.53% for AIS, 26.60% for EGD, 16.03% for benign. p53 overexpression was noted in 4 (18%) cases of IA, 3 (20%) of AIS, but none of EGD and benign lesions. It was Interesting to note that one case of MGH showed p53 staining in low intensity. Diffuse strong cytoplasmic CEA positivity was present in all of IA and AIS, whereas seven (47%) of 15 EGD and 12 (41%) of 29 benign lesions showed focal cytoplasmic CEA positivity. There were significant differences in MIB-1 and CEA immunostainings among the adenocarcinoma, EGD, and benign glandular lesions. Adenocarcinoma was closely related to p53 overexpression, although occurring in a low percentage of the cases.
Conclusion: MIB-1 immunostaining can be useful in differentiating among endocervical adenocarcinoma, endocervical glandular dysplasia and benign glandular lesions. p53 overexpression might be helpful in the diagnosis of adenocarcinoma.
키워드
Endocervical adenocarcinoma;Endocervical glandular dysplasia;MIB-1;p53;CEA
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