Microsatellite Instability in Colorectal Carcinomas
차희정, 우동균, 김선희, 김용일, 박재갑, 김우호,
소속 상세정보
차희정 ( Cha Hee-Jung )
서울대학교 의과대학 병리학교실
우동균 ( Woo Dong-Kyun )
서울대학교 의과대학 암연구소
김선희 ( Kim Sun-Hee )
서울대학교 의과대학 병리학교실
김용일 ( Kim Yong-Il )
서울대학교 의과대학 병리학교실
박재갑 ( Park Jae-Gahb )
서울대학교 의과대학 외과학교실
김우호 ( Kim Woo-Ho )
서울대학교 의과대학 병리학교실
KMID : 0357920010350020111
Abstract
Background: Microsatellite instability (MSI), which is caused by a deficient mismatch repair system, is seen in most of the hereditary non-polyposis colon cancers and a portion of sporadic colorectal cancers.
Methods: Two hundreds forty-six consecutive sporadic colorectal cancer patients were analyzed for MSI using an ABI 377 automatic sequencer and fluorescent dye-labelled primers (BAT-25 and BAT-26).
Results: The overall incidence of MSI in studied cases was 9.8% (24/246). This incidence is lower than most of the reported incidences in western countries. The incidence of MSI tumors in the proximal colon was 29.6%, while that of the distal colon was only 4.2% (p<0.001). MSI in sporadic colorectal cancers was more prevalent in poorly differentiated adenocarcinoma. In contrast to western countries, mucinous carcinoma did not show higher incidence of MSI.
Conclusions: The results suggest that MSI frequently occurs in cancers of the proximal colon and in tumors with poorly differentiated histology.
키워드
Colorectal neoplasms;Microsatellite repeats;Sequence analysis
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