인체 결직장 암종에서 Transforming Growth Factor-β1 및 그 수용체 발현
The Expression of Transforming Growth Factor-β1 and Its Signaling Receptors in HumanColorectal Carcinoma
김경선, 김주헌, 문우성, 정명자, 이동근, 강명재,
소속 상세정보
김경선 ( Kim Gyeong-Seon )
전북대학교 의과대학 병리학교실
김주헌 ( Kim Ju-Hun )
을지대학교 의과대학 병리학교실
문우성 ( Moon Woo-Sung )
전북대학교 의과대학 병리학교실
정명자 ( Chung Myoung-Ja )
전북대학교 의과대학 병리학교실
이동근 ( Lee Dong-Geun )
전북대학교 의과대학 병리학교실
강명재 ( Kang Myoung-Jae )
전북대학교 의과대학 병리학교실
KMID : 0357920010350020115
Abstract
Background: Resistance to the potent growth inhibitory effects of TGF-β (transforming growth factor-β) is a characteristic of many malignancies. TGF-β insensitivity has been attributed to alterations in the number and function of the TGF-β receptors as well as disturbances of downstream signal transduction. The aim of this study was to examine the expression of TGF-β1 and its receptors in human colorectal cancer tissue and determine its relationship with cancer growth and with prognostic factors.
Methods: Immunohistochemical staining of TGF-β1, TGF-βRI, and TGF-βRII was performed on 20 human colorectal adenomas, 30 carcinomas and 10 normal mucosas as a control.
Results: The staining indices of TGF-β1, TGF-βRI, and TGF-βRII increased in adenomas and carcinomas compared with normal mucosas and adenomas, respectively. In adenomas the staining index of TGF-β1 significantly increased with the severity of atypism. The staining index of TGF-βRII increased in the carcinomas in the right colon and rectum, compared with those in the left colon.
Conclusions: The enhanced expression of TGF-β1, TGF-βRI and II in the colorectal carcinoma suggests an important role of colorectal carcinogenesis and tumor progression.
키워드
Colorectal neoplasms;Transforming growth factor beta;Receptors;Immunohistochemistry
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