피부 악성 흑색종에서 p53 유전자 돌연변이의 인종간의 차이
Ethnic Differences of the p53 Genetic Alteration in Cutaneous Malignant Melanoma
박원상, 나은영, 이상규, 이석형, 김수영, 강석진, 송계용, 남석우, 유남진, 이정용,
소속 상세정보
박원상 ( Park Won-Sang )
가톨릭대학교 의과대학 병리학교실
나은영 ( Na Eun-Young )
가톨릭대학교 의과대학 병리학교실
이상규 ( Lee Sang-Kyu )
가톨릭대학교 의과대학 병리학교실
이석형 ( Lee Sug-Hyung )
가톨릭대학교 의과대학 병리학교실
김수영 ( Kim Su-Young )
가톨릭대학교 의과대학 병리학교실
강석진 ( Kang Seok-Jin )
가톨릭대학교 의과대학 병리학교실
송계용 ( Song Kye-Yong )
중앙대학교 의과대학 병리학교실
남석우 ( Nam Suk-Woo )
미국 국립보건원 병리실험실
유남진 ( Yoo Nam-Jin )
가톨릭대학교 의과대학 병리학교실
이정용 ( Lee Jung-Young )
가톨릭대학교 의과대학 병리학교실
KMID : 0357920010350020158
Abstract
Background: There are significant differences in the clincopathologic pattern including the incidence, favor site, and histopathologic type between cutaneous malignant melanomas arising from whites, asians and blacks. These differences might suggest that there is a racial difference in the molecular tumorigenesis mechanism of malignant melanoma.
Methods: To determine the ethnic differences in tumorigenesis of malignant melanoma, we performed loss of heterozygosity (LOH) and sequencing analyses of the p53 gene in cutaneous malignant melanomas arising from 22 white American, 30 Korean and 15 black African patients.
Results: The frequency of LOH of the p53 gene is only 12.5% in white American patients, but the frequency is significantly higher in Korean (42.1%) and black African (61.5%) patients. We also detected 17 mutations (nonsense: 1, missense: 16) of the p53 gene in the cutaneous malignant melanomas of Koreans and black Africans, but none in those of white Americans: among the 16 missense mutations, 10 mutations were C:G to T:A transitional mutations. Of these, we also detected one GG (CC) to AA (TT) tandem mutation at the pyrimidine sequence.
Conclusions: These results strongly suggest that there might be a racial difference in molecular carcinogenesis mechanisms among the cutaneous malignant melanomas occurring in white American, Korean and black African patients. But the role of the p53 genetic alteration in the genesis of melanomas in Korean and black African patients
is subject to further evaluation.
키워드
p53;Mutation;Loss of heterozygosity;Melanoma;Ethnic group
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