후천성면역결핍증 환자에서 전자현미경검사로 확진된 폴리오마바이러스의 콩팥 감염 - 1부검례 보고 -
Polyomavirus Renal Infection Confirmed by Electron Microscopy in a Patient with AcquiredImmunodeficiency Syndrome - An Autopsy Case Report -
김나래, 김병권, 지제근,
소속 상세정보
김나래 ( Kim Na-Rae )
서울대학교 의과대학 병리학교실
김병권 ( Kim Byoung-Kwon )
서울대학교 의과대학 병리학교실
지제근 ( Chi Je-Geun )
서울대학교 의과대학 병리학교실
KMID : 0357920010350020168
Abstract
Polyomavirus infection commonly occurs in childhood and adolescence, remaining in a latent status and reactivated in an immunocompromised status. We report herein an autopsy case of HIV-positive 41-year-old male, who succumbed to disseminated Kaposi sarcoma and cytomegalovirus infection involving the gastrointestinal tract, lung and brain. The involved kidney showed minimal inflammatory infiltrates and tubular injury: the nuclei of tubular epithelial cells were markedly enlarged with central clearing and peripheral chromatin margination or bore basophilic nuclear inclusions. Inclusion-bearing tubular epithelial cells were negative for the viral immunostains including herpes simplex virus, Epstein-Barr virus and adenovirus. Electron microscopy disclosed 42 nm intranuclear viral particles compatible with the BK polyomavirus. The viral particles were icosahedral in paracrystalline array and nonenveloped.
키워드
Polyomavirus;HIV;Kidney;Electron Microscopy
원문 및 링크아웃 정보
등재저널 정보