Atypical (Bizarre) Leiomyoma of the Prostate - A Case Report -
김성림, 송상용, 안긍환, 최한용,
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김성림 ( Kim Sung-Rim )
성균관대학교 의과대학 삼성서울병원 진단병리과
송상용 ( Song Sang-Yong )
성균관대학교 의과대학 삼성서울병원 진단병리과
안긍환 ( Ahn Geung-Hwan )
성균관대학교 의과대학 삼성서울병원 진단병리과
최한용 ( Choi Han-Yong )
성균관대학교 의과대학 삼성서울병원 비뇨기과학교실
KMID : 0357920010350020172
Abstract
Atypical (bizarre) leiomyoma of the prostate is a very rare neoplasm. Five cases have been reported in English medical literature. A 60-year-old Korean man with a history of prostatism and slightly elevated serum prostate specific antigen was presented. Microscopically, the transurethral resection specimen consisted of a proliferation of hypercellular spindle cells with intersecting bundles. The nuclei of the tumor cells showed marked pleomorphism and hyperchromasia with occasional multinucleated giant cells. Mitoses were seen in areas of up to 2 per 10 high power fields, but there was no evidence of atypical ones. The tumor cells were immunoreactive against anti-smooth muscle actin and desmin antibodies. The proliferative index (10.0%) of the atypical leiomyoma lay between that of a benign smooth muscle and that of a leiomyosarcoma of the prostate. Flow cytometry showed a diploid pattern with an elevated S phase fraction. To the best of our knowledge, this is the first demonstration of atypical leiomyoma of the prostate in a Korean man.
키워드
Leiomyoma;Leiomyosarcoma;Uncertainties;Prostate
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