파라핀에 포매한 형질세포종양 조직에서의 CD56의 발현 증가와 진단적 유용성
The Increased Expression and Diagnostic Usefulness of CD56 Antigen in Paraffin Embedded Plasma Cell Neoplasm
김석형, 강현욱, 박성호, 정두현, 박찬식, 최은영,
소속 상세정보
김석형 ( Kim Seok-Hyung )
서울대학교 의과대학 병리학교실
강현욱 ( Kang Hyun-Wook )
제주대학교 의학전문대학원 병리학교실
박성호 ( Park Seong-Hoe )
서울대학교 의과대학 병리학교실
정두현 ( Chung Doo-Hyun )
서울대학교 의과대학 병리학교실
박찬식 ( Park Chan-Sik )
서울대학교 의과대학 병리학교실
최은영 ( Choi Eun-Young )
서울대학교 의과대학 병리학교실
KMID : 0357920010350030201
Abstract
Background: The natural killer cell antigen CD56 (NCAM) is a member of the immunoglobulin superfamily and is expressed on neurons, astrocytes, and Schwann cells. Recently, it has been reported that CD56 expression is detected on plasma cells of multiple myeloma by flow cytometry.
Method: In this study, to test the diagnostic usefulness of the anti-CD56 antibody for plasma cell neoplasm on paraffin-embedded materials, we performed immunohistochemical staining of samples from 19 patients with plasma cell neoplasms. These cases included 14 cases of multiple myeloma, 3 cases of solitary plasmacytoma of the bone, and two cases of extramedullary plasmacytoma.
Results: The neoplastic plasma cells from 68 % of the patients with plasma cell neoplasms expressed CD56 highly. CD56 was expressed in all three cases of solitary plasmacytoma of the bone and one of two extramedullary plasmacytoma, and nine out of 14 multiple myeloma cases. In contrast, reactive plasma cells from the 18 patients with miscellaneous lesions were completely negative for CD56.
Conclusions: CD56 is aberrantly expressed on the neoplastic plasma cells, and it may be used as a useful marker for the diagnosis of plasma cell neoplasms in paraffin-embedded tissues.
키워드
CD56;Plasma cell;Multiple myeloma;Plasmacytoma;Immunohistochemistry
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