인유두종 바이러스 양성 및 음성 침윤성 자궁경부암종에서 p53, p21, mdm2 단백의 발현
Immunohistochemical Expression of p53, p21, and mdm2 Proteins in Human Papillomavirus Positive and Negative Invasive Uterine Cervical Carcinomas
박인서, 한혜승, 김태숙, 한지영, 김준미, 주영채, 황태숙,
소속 상세정보
박인서 ( Park In-Seo )
인하대학교 의과대학 병리학교실
한혜승 ( Han Hye-Seung )
인하대학교 의과대학 병리학교실
김태숙 ( Kim Tae-Sook )
인하대학교 의과대학 병리학교실
한지영 ( Han Jee-Young )
인하대학교 의과대학 병리학교실
김준미 ( Kim Joon-Mee )
인하대학교 의과대학 병리학교실
주영채 ( Chu Young-Chae )
인하대학교 의과대학 병리학교실
황태숙 ( Hwang Tae-Sook )
인하대학교 의과대학 병리학교실
KMID : 0357920010350030212
Abstract
Background: In the uterine cervical carcinoma, the inactivation of p53 protein by human papillomavirus(HPV) E6 protein has been reported to play a greater role in carcinogenesis than the mutation of the p53 gene. Therefore, the mutation of the p53 gene is rare. p21 and mdm2 proteins are induced by wild-type p53 protein and are involved in the cell cycle regulatory mechanism.
Methods: Immunohistochemical staining for p53, p21 and mdm2 proteins was performed in 26 HPV-positive and 13 HPV-negative invasive cervical carcinomas together with 5 non-neoplastic cervical tissues.
Results: The frequencies of the expression of p53, p21 and mdm2 proteins were 82.1%, 84.6% and 66.7%, respectively. The expression of p53 protein was less frequently demonstrated in HPV-positive cases than HPV-negative cases, which was statistically a negative correlation(p=0.018). The expression of p53 and p21 proteins was statistically significant(p=0.000).
Conclusions: p53, p21 and mdm2 proteins were highly expressed in both HPV-positive and HPV-negative cervical carcinomas. Significantly higher expression of p53 protain in HPV-negative cases necessitate a further study for investigating the role of p53 protein accumulation in carcinogenesis of HPV-negative cervical carcinomas. The relationship between the expression of p53 protein and p21/mdm2 proteins may indicate that p21 and mdm2 proteins also have a role in carcinogenesis, where p53 protein plays a fundamental role.
키워드
Cervical neoplasms;Protein p53;p21WAF1/CIP1/SDI1;Murine double minute 2;Papillomavirus
원문 및 링크아웃 정보
등재저널 정보