난소의 장액성 종양에서의 p27kip1과 Cyclin D1 발현에 대한 조사
Expression of p27kip1 and Cyclin D1 in Serous Epithelial Ovarian Tumors
권선영, 장은숙, 권건영, 박관규, 김수경,
소속 상세정보
권선영 ( Kwon Sun-Young )
계명대학교 의과대학 병리학교실
장은숙 ( Chang Eun-Sook )
계명대학교 의과대학 병리학교실
권건영 ( Kwon Kun-Young )
계명대학교 의과대학 병리학교실
박관규 ( Park Kwan-Kyu )
계명대학교 의과대학 병리학교실
김수경 ( Kim Soo-Kyung )
계명대학교 의과대학 약리학교실
KMID : 0357920010350030220
Abstract
Background: p27kip1 is a member of the Cip/Kip family of the cyclin-dependent kinase inhibitors and is a potential tumor suppressor gene. Decreased expression of p27kip1 is associated with high histologic grade and poor prognosis in a variety of human tumors.
Methods: Sixty-six cases of serous epithelial ovarian tumors were investigated by immunohistochemical staining for p27kip1, cyclin D1, and Ki-67. Clinicopathologic parameters (WHO classification, histologic grade and FIGO stage) were compared with the incidence of p27kip1, cyclin D1 and Ki-67 protein expression in ovarian serous tumors.
Results: Reduced expression of p27kip1 was found more freguently in serous cystadenocarcinoma than in serous cystadenoma and borderline malignancy (p<0.05). The decreased expression of p27kip1 was correlated with a high histologic grade and an advanced FIGO stage. Overexpression of cyclin D1 is associated with borderline malignancy and grade I serous cystadenocarcinoma. An inverse relationship was observed between the p27kip1 protein and the Ki-67 labeling index within serous cystadenocarcinoma, but it was not significant.
Conclusions: Reduced expression of p27kip1 protein plays an important role in the biologically aggressive behavior of serous epithelial ovarian tumors and might represent a useful prognostic marker for predicting the recurrence in primary ovarian tumors.
키워드
p27;Cyclin D1;Ovarian neoplasms;Epithelial
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