편평세포암종이 동반된 비강의 도립유두종 - 2예 보고 -
Nasal Inverted Papilloma Associated With Squamous Cell Carcinoma - A Report of Two Cases -
구미진, 김동석, 배영경, 김용대,
소속 상세정보
구미진 ( Gu Mi-Jin )
영남대학교 의과대학 병리학교실
김동석 ( Kim Dong-Sug )
영남대학교 의과대학 병리학교실
배영경 ( Bae Young-Kyung )
영남대학교 의과대학 병리학교실
김용대 ( Kim Yong-Dae )
영남대학교 의과대학 이비인후과학교실
KMID : 0357920010350030248
Abstract
Nasal inverted papilloma (IP) is a benign neoplasm that may be associated with squamous cell carcinoma (SCC). Several studies have suggested that human papilloma virus 16/18 (HPV 16/18) and p53 are closely related to the pathogenesis of IP with transformation to squamous cell carcinoma (IP-SCC). This study was conducted to investigate the role of HPV 16/18 and p53 in the pathogenesis of IP-SCC using immunohistochemistry. We studied two cases of IP-SCC and 10 cases of IP. None of the IP cases presented positivity for HPV 16/18 or p53 protein. Two cases of IP-SCC showed negative reactions for HPV 16/18. The SCC portion of the IP-SCC showed strong positivity for p53, while the IP portion of the IP-SCC was negative for p53. MIB-1 labeling index (LI) was estimated in the IP cases and the IP-SCC as well. In terms of MIB-1 LI, there was no statistical significance between IP and IP-SCC, and between the IP portion and the SCC portion in the cases of IP-SCC. In conclusion, we believe that alteration of the p53 protein is related to IP with malignant transformation, but further studies are required to investigate the correlation of HPV 16/18 and p53 in the pathogenesis of IP with malignant transformation, and the significance of the MIB-1 LI and p53 as biomarkers in IP.
키워드
Inverted papilloma;Squamous cell carcinoma;Human papillomavirus 16/18; 53
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