위선종과 위암종에 이써서 Caspase 3와 Ki-67 발현 및 세포자멸사와의 관련성
Caspase 3 and Ki-67 Immunoreactivity and Its Correlation with Frequency of Apoptosis in Gastric Adenomas and Carcinomas
손진희, 신형식, 최경찬, 채승완,
소속 상세정보
손진희 ( Sohn Jin-Hee )
한림대학교 의과대학 병리학교실
신형식 ( Shin Hyung-Sik )
한림대학교 의과대학 병리학교실
최경찬 ( Choi Kyung-Chan )
한림대학교 의과대학 병리학교실
채승완 ( Chae Seoung-Wan )
한림대학교 의과대학 병리학교실
KMID : 0357920010350040286
Abstract
Background: Apoptosis, also known as programmed cell death, is under genetic control and is mediated by apoptosls-specific genes, cartain oncogenes and tumor suppressor genes. Caspase 3, a group of cystein proteases, is involved in the induction of apoptosis and has been considered to be correlated with apoptosis. Therefore, we tried to define whether caspase 3 is expressed in gastric adenoma and carcinoma, and correlated with apoptosis.
Methods: The apoptotic index and caspase 3 and Ki-67 immunoreactivity were observed in 25 gastric adenomas, 31 early gasfric carcinomas(EGC) and 64 advanced gastric carcinomas （AGC） by in situ labelling and immunohistochemistry.
Resulits: The mean number of apoptotic bodies and caspase 3 immunoreactivity were signifcantly increased from adenoma through EGC to AGC. Ki-67 immunoreactivity was more increased in AGC than in adenoma and EGC. And the number of apoptotic bodies were positively correlated with caspase 3 and Ki-67 immunoreactivity, and caspase 3 immunoreactivity was negatively correlated with Ki-67 immunoreactivity even though they were statistically insignificant.
Concluslons: Our results suggest that caspase 3 activation is important for inducing apopfosis, and both caspase 3 and apoptosis are increased along the tumor progression.
키워드
Apoptosis;Caspases;Ki-67 antigen;Carcinoma;Stomach
원문 및 링크아웃 정보
등재저널 정보