비소세포성 폐암종에서 Extracellular Signal Regulated Kinase (ERK)의 발현
The Expression of Extracellular Signal Regulated Kinase (ERK) in Non-Small Cell Lung Carcinoma
김세훈, 김형중, 박영년, 조상호,
소속 상세정보
김세훈 ( Kim Se-Hoon )
연세대학교 의과대학 병리학교실
김형중 ( Kim Hyung-Jung )
연세대학교 의과대학 내과학교실
박영년 ( Park Young-Nyun )
연세대학교 의과대학 병리학교실
조상호 ( Cho Sang-Ho )
연세대학교 의과대학 병리학교실
KMID : 0357920010350050361
Abstract
Background: Although it was suggested that constitutive extracellular signal regulated kinase (ERK) activation plays a pivotal role in intracellular signal transduction related to oncogenesis, a consistent relationship between constitutive ERK activation and oncogenesis has not yet been clearly demonstrated. The purpose of this study is to evaluate the expression frequencies and pattern of phosphorylated ERK (p-ERK) in the non-small cell lung carcinoma (NSCLC) and to evaluate whether p-ERK is a useful prognostic factor.
Methods: One hundred sixty cases of NSCLC tissue specimens were investigated by immunohistochemical staining for p-ERK. Clinicopathologic values (tumor stage, cell type, differentiation and presence of metastasis) and p-ERK expression of normal alveolar pneumocytes around NSCLC were compared with the incidence of tumor p-ERK expression.
Results: Fifty-three out of 160 cases (33%) of NSCLC showed expression of p-ERK. There was no statistical correlation between the expression of p-ERK in the NSCLC neoplastic cells and the corresponding tumor stage, cell type and presence of metastasis. There was statistical significance between the expressions of p-ERK in alveolar pneumocytes around NSCLC (odds ratio: 6.130).
Conclusions: Based on these results, we suggest that p-ERK expression is not useful in predicting the prognosis of NSCLC. In regard to the theory of “field cancerization” and the phenomenon of “allele-specific loss or allele-specific mutations”, the statistically significant p-ERK expression in alveolar pneumocytes around NSCLC suggests that constitutive ERK activation is involved in the early stage of NSCLC carcinogenesis rather than in proliferation, differentiation or metastasis of NSCLC.
키워드
Mitogen-activated protein kinase;Immunohistochemistry;Carcinoma;non-small cell;Lung
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