위암 발생 과정에서 β-Catenin의 역할
β-Catenin Expression in Gastric Carcinogenesis
강혜윤, 최연락, 김호근,
소속 상세정보
강혜윤 ( Kang Hae-Youn )
연세대학교 의과대학 병리학교실
최연락 ( Choi Yon-Rak )
연세대학교 의과대학 병리학교실
김호근 ( Kim Ho-Guen )
연세대학교 의과대학 병리학교실
KMID : 0357920010350050376
Abstract
Background: The molecular pathogenesis of gastric carcinoma is not yet well characterized. The purpose of this study is to assess the role of β-catenin in gastric carcinogenesis.
Methods: We analyzed β-catenin expression using immunohistochemistry on 68 gastric adenomas and 34 gastric adenocarcinomas, and compared the result with pathological and molecular types of tumors and E-cadherin expression.
Results: Nuclear expression of β-catenin was noted more frequently in gastric adenomas than in carcinomas (40% vs. 21%, 0.05≤p<1). There was no significant relationship between nuclear β-catenin expression and histologic degree of adenoma, histologic type of carcinoma or microsatellite instability. E-cadherin expression showed significantly more frequent decrease in the membrane stainability of carcinomas compared to adenomas (p<0.01).
Conclusions: The frequent nuclear β-catenin expression in gastric adenomas suggests that the β-catenin alteration might play an early role in gastric carcinogenesis.
키워드
Stomach neoplasms;Beta catenin;Cadherins;Microsatellite repeats
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