자궁경부암종에서 암 전이의 조기 발견을 위한 면역조직화학 연구
Early Detection of Metastasis by Immunohistochemistry in Uterine Cervical Carcinoma
박관규, 권선영, 제갈문영, 한상미, 장은숙, 차순도, 한인숙,
소속 상세정보
박관규 ( Park Kwan-Kyu )
계명대학교 의과대학 병리학교실
권선영 ( Kwon Sun-Young )
계명대학교 의과대학 병리학교실
제갈문영 ( Jegal Moon-Young )
계명대학교 의과대학 병리학교실
한상미 ( Han Sang-Mi )
계명대학교 의과대학 병리학교실
장은숙 ( Chang Eun-Sook )
계명대학교 의과대학 병리학교실
차순도 ( Cha Soon-Do )
계명대학교 의과대학 산부인과학교실
한인숙 ( Han In-Sook )
경북대학교 의과대학 면역학교실
KMID : 0357920010350050391
Abstract
Backkground: Adhesion molecules are important in the maintenance of normal epithelial structure, and altered expression of these molecules may be important in epithelial tumors, particularly in the processes of invasion and metastasis.
Methods: We have examined the expression of E-cadherin, cathepsin-D, CD44, CD44v6, nm23 and transforming growth factor-1 (TGF-1) proteins in the cervical squamous cell carcinoma to evaluate the prognostic significance of these molecules.
Results: Immunostain for E-cadherin was highly expressed in the majority of cases of cervical carcinomatous lesions (85.7-100%), but cathepsin-D was very low (7.1-32%). Immunostain for CD44 showed a lower expression in invasive carcinoma with and without metastasis (50.4 and 52.2%) than in carcinoma in situ (68.0%). CD44v6 protein showed some controversy of expression between invasive carcinoma with metastasis (35.7%) without metastasis (56.5%). Staining for nm23 was observed in the high expression of invasive lesions (85.7%). TGF-1 and C-erbB-2 protein were highly expressed, especially in the microinvasive carcinoma (81.8%, 42.8%, respectively).
Conclusions: These results suggest that CD44 and CD44v6 were not highly expressed in the invasive squamous carcinoma of the uterine cervix. However, it is notable that TGF-1 and c-erbB-2 in the microinvasive carcinoma and nm23 in invasive carcinoma were highly expressed compared to these of the other lesions of the uterine cervix.
키워드
Metastasis;Cervix uteri;Squamous cell carcinoma;Immunohistochemistry
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