Rasmussen 뇌염- 1예 보고 -
Rasmussen’’s Encephalitis - A Case Report -
김나래, 한재준, 서연림, 이문향,
소속 상세정보
김나래 ( Kim Na-Rae )
지방공사 강남병원 해부병리과
한재준 ( Han Jae-Joon )
성균관대학교 의과대학 삼성서울병원 진단병리과
서연림 ( Suh Yeon-Lim )
성균관대학교 의과대학 삼성서울병원 진단병리과
이문향 ( Lee Mun-Hyang )
성균관대학교 의과대학 삼성서울병원 소아과학교실
KMID : 0357920010350050455
Abstract
We herein report a case of intractable epilepsy that occurred in a 7-year-old girl, which is consistent with radiological and clinicopathological hallmarks of Rasmussen’s encephalitis. The patient showed characteristic primary unilateral involvement with secondary bilateral propagation. Microscopically, the cortical atrophy due to neuronal loss, intense GFAP-immunoreactive astrogliosis, neuronophagia, perivascular lymphocytic infiltration and microglial nodules was seen throughout the cortex and white matter. No viral inclusions were noted; no cytomegalovirus, herpes simplex virus or Epstein-Barr virus was found by in situ hybridization. Granular immunofluorescence for C4, C1q and IgG within the blood vessel walls was noted, and ultrastructurally, only nonspecific vascular injury was found. Rasmussen’s encephalitis is a diagnosis of exclusion; it can be diagnosed by the combination of clinical manifestation, neuroimaging and characteristic pathologic features.
키워드
Encephalitis;Immunohistochemistry;in situ hybridization;Fluorescent Antibody Technique;Electron Microscopy
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