수모세포종에서 면역조직화학 염색에 의한 분화형, 증식능, Caspase 3 표현율과 예후와의 관계
Differentiation, Proliferative Index, and Caspase 3 Expression Rate in the Immunohistochemical Stains of Medulloblastoma as Prognostic Factors
김성은, 양우익, 김태승,
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김성은 ( Kim Sung-Eun )
연세대학교 의과대학 병리학교실
양우익 ( Yang Woo-Ick )
연세대학교 의과대학 병리학교실
김태승 ( Kim Tai-Seung )
연세대학교 의과대학 병리학교실
KMID : 0357920010350060536
Abstract
Background : Medulloblastoma is a highly malignant neuroepithelial tumor of the childhood, less frequently, of adults, located in the posterior cranial fossa. It shows multiple lines of differentiation, expressing neuronal, glial, mesenchymal and ectodermal markers. The prognostic significance of cell differentiation has been studied, but received little agreement. In highly malignant tumors, very high proliferative index has been demonstrated. A major contributor to cell loss in medulloblastoma is reported to be apoptosis. In medulloblstoma, a linear relation between apoptotic index and proliferative index has not been convincingly demonstrated.
Methods : We analyzed the immunohistochemical features, proliferative indices and apoptotic indices in medulloblastoma patients with regard to their clinical courses. Clinical features of 58 patients with medulloblastoma were reviewed. The presence of glial fibrillary acidic protein, synaptophysin, vimentin, and epithelial membrane antigen
were examined with immunohistochemical method. The proliferative index (Ki-67) and caspase 3 expressing rate were calculated.
Results : There was no significant correlation between the prognosis and the degree of ceal differentiation. The positive correlation was noted between proliferative index and apoptotic index in a tumor mass.
Conclusions : Only proliferative index could be used as a prognostic factor.
키워드
Medulloblastoma;Immunohistochemistry;Ki-67 antigen;Apoptosis;Caspases
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