척수에 발생한 원발성 호산성 과립세포성 부신경절종 -1예 보고-
Primary Spinal Oncocytic Paraganglioma -A Case Report-
이지혜, 박성환, 조현득, 염범우, 최종상, 김철환, 서연림,
소속 상세정보
이지혜 ( Lee Ji-Hye )
고려대학교 의과대학 병리학교실
박성환 ( Park Seong-Hwan )
고려대학교 의과대학 병리학교실
조현득 ( Cho Hyun-Duk )
고려대학교 의과대학 병리학교실
염범우 ( Yeom Bom-Woo )
고려대학교 의과대학 병리학교실
최종상 ( Choi Jong-Sang )
고려대학교 의과대학 병리학교실
김철환 ( Kim Chul-Hwan )
고려대학교 의과대학 병리학교실
서연림 ( Suh Yeon-Lim )
성균관대학교 의과대학 삼성서울병원 진단병리과
KMID : 0357920010350060561
Abstract
Paraganglioma is a generic term applied to tumors of paraganglia, regardless of location, and composed largely of paraganglionic chief cells. It is a rare tumor, especially in the spinal region. When it appears in the craniospinal axis, it is restricted to the cauda equina or filum terminale, and less commonly, the spinal nerve root. We report a case of oncocytic paraganglioma in the spinal nerve root of 13-year-old girl. The tumor was located in intradural and extramedullary areas from the 12th thoracic to the 1st lumbar vertebra. Histologically, the tumor cells with abundant eosinophilic cytoplasms show diffuse compact clusters, which are surrounded by fibers in a reticulin stain, like a nested pattern. The nuclei are round to ovoid in shape with mild atypia. Immunohistochemically, the tumor cells are positive for synaptophysin, neuron-specific enolase and vimentin but are negative for cytokeratin, chromogranin and glial fibrillary acidic protein. Some cells are positive for S-100 protein. The MIB-1 labeling index is low. Ultrastructurally, dense core neurosecretory granules are not found but mitochondrias are commonly noted.
키워드
Paraganglioma;Spinal canal
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