Mixed Germ Cell-Sex Cord-Stromal Tumor of Non-Gonadoblastoma Type of Ovary: A Case Report
민광선, 최병하, 김규래,
소속 상세정보
민광선 ( Min Kwang-Seon )
울산대학교 의과대학 서울아산병원 병리학교실
최병하 ( Choi Byung-Ha )
울산대학교 의과대학 서울아산병원 병리학교실
김규래 ( Kim Kyu-Rae )
울산대학교 의과대학 서울아산병원 병리과
KMID : 0357920020360010062
Abstract
We described a case of mixed germ cell-sex cord-stromal tumor of non-gonadoblastoma type (GCSCT-NG)of the ovary in a 2-year-old girl and compared its histological, immunohistochemical and ultrastructural findings with those of gonadoblastoma. The germ cell component showed an immunopositivity for cytokeratin and epithelial membrane antigen(EMA) and a negative reaction for α-inhibin, alpha-fetoprotein(AFP), placental alkaline phosphatase (PLAP), vimentin and CD99. The sex cord elements showed an immunopositivity for cytokeratin, EMA, vimentin and inhibin, but negativity for AFP, PLAP, and CD99. The ultrastructural features showed desmosome-like cell junctions, suggesting spermatocytic differentiation from the primordial germ cells or gonocytes. Immunohistochemical and ultrastructural findings suggested that GCSCT-NG is probably a more differentiated form of mixed germ cellsex cord-stromal tumor than gonadoblastoma.
키워드
Ovarian Neoplasms;Sex Cord;Stromal Tumor
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