칼시토닌 발현과 아밀로이드 축적을 보인 중이의 유암종 -1예 보고-
Calcitonin Producing Middle Ear Carcinoid with Amyloid Deposition -A Case Report-
임범진, 양우익, 홍순원, 박찬일,
소속 상세정보
임범진 ( Lim Beom-Jin )
연세대학교 의과대학 병리학교실
양우익 ( Yang Woo-Ick )
연세대학교 의과대학 병리학교실
홍순원 ( Hong Soon-Won )
연세대학교 의과대학 병리학교실
박찬일 ( Park Chan-Il )
연세대학교 의과대학 병리학교실
KMID : 0357920020360020115
Abstract
Carcinoid tumor of the middle ear cavity is a rare neoplasm of low malignant potential. It grows slowly and rarely metastasizes. We recently experienced a case of carcinoid tumor of the middle ear cavity occurring in a 51-year-old female who was presented with hearing loss and tinnitus of the right ear. A 1 ㎝ sized pinkish soft mass was noted in the promontory of the middle ear. Histologically, the mass was composed of nests and cords of tumor cells with slightly plemorphic nuclei and eosinophilic cytoplasm. The extracellular matrix was glassy pink, homogeneous and exhibited apple green birefringence under a polarized light microscope after Congo red staining. The tumor cells showed immunoreactivity for cytokeratin, chromograinin A, synaptophysin, neuron-specific enolase and calcitonin. Electron microscopic examinatin confirmed the presence of neurosecretory granules. The production of calcitonin and amyloid by the tumor cells suggests the possible relationship of this tumor to the thyroid C cells.
키워드
Carcinoid Tumor;Ear;Middle;Calcitonin;Amyloid
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